The reel is too long. I know everything you do is prescious to you, but employers don’t care. Keep it short, keep it punchier. I’d also try and minimize the instances of straight video in the reel: it looks cheap.
If the reel is what you most want people to see, place it prominently. Right now, you need to dig. There’s way too much navigation overall. An employer is not going to be browsing your page: they want to click the link, see the work, and move on to the tons of other applications they have. I’d pick 10 of your best pieces, and create a single page to focus on them. Put your reel prominently at the top. Make it available in QT, WMV, and viewable online in flash. You want it to be as easy as possible for an employer to see your work.
I’d really think about cutting some of the work as well. The webpage design section can go outright. PS2 cheats is not as good as the portfolio page itself, and should not be mentioned. I’d place Aesthete most prominently beyond the demo reel: it’s probably your second best work.
Essentially, you’ve got a jack-of-all-trades master of none portfolio here. You need to pick what you’re applying for, and make the portfolio match. If that means 2 or 3 distinct portfolios, then so be it, but someone hiring you to work on motion graphics doesn’t need to see your musical experience, nor would a design firm care.
Best of luck. Hopefully this criticism is useful and isn’t too harsh.